Acamprosate is a medication most commonly used to treat alcohol use disorder.1 When used safely, this medication can help people struggling with alcoholism to achieve and maintain abstinence.
This article answers common questions about acamprosate, including:
What Is Acamprosate?
Acamprosate is not a cure for alcohol use disorder . 4 It is most effective if combined with psychosocial interventions such as cognitive behavioral therapy and motivational interviewing . 5 Twelve-step programs such as Alcoholics Anonymous can also be helpful because they provide an opportunity for you to bond with people who have similar struggles. 5
How Does It Work?
Acamprosate works by rebalancing the amount of excitatory and inhibitory signals in the brain. 2
Communication within the nervous system is mediated by signaling chemicals known as neurotransmitters. These neurotransmitters can be classified as either excitatory or inhibitory, depending on how they affect brain cells.3 When balanced, these neurotransmitters keep your brain and body working correctly. However, too much of either can lead to seizures, stroke, coma or death. 3
Long-term alcohol abuse causes your brain to produce too many excitatory and too few inhibitory neurotransmitters.3 It teaches your brain that it no longer needs to produce its own inhibitory signals because you will supply them yourself with alcohol.3
By blocking an excitatory receptor called N-methyl-D-aspartate (NMDA), acamprosate reduces the excess of excitatory messages and increases the amount of inhibitory messages. 2 For this reason, some experts refer to acamprosate as "artificial alcohol."2 Ultimately, acamprosate helps reduce cravings and prevent relapse . 1
Where Can You Get It?
Your primary care provider can prescribe this medication. But it is usually best to receive care from an addiction medicine specialist - specifically a psychiatrist or a psychiatric nurse practitioner at either a mental health or a substance abuse clinic.4
Acamprosate should only be taken under the guidance of a medical professional.
Acamprosate Side Effects
Up to 17% of users report diarrhea after taking acamprosate, making it the most common side effect. 1 Other potential side effects include weight gain and sedation. However, these are rare.2
Serious Adverse Effects
Serious adverse effects include:
Cardiomyopathy (the heart struggles to deliver blood to the body - can lead to heart failure).
Deep thrombophlebitis (inflammation of veins due to a blood clot).
Mesenteric arterial occlusion (blockage of the arteries that supply blood to the digestive tract).1
About 1% to 2.4% of users experience suicidal ideation while taking acamprosate. 1 This is more likely to occur if those who have attempted suicide in the past. 1 It will be important to discuss symptoms with your healthcare provider if you begin to feel down, depressed or hopeless while taking Acamprosate.
Acamprosate appears to be safe for long-term use. However, extensive research on this has not been conducted. 1
As with any new medication, you may be at risk of developing an allergic reaction when acamprosate therapy is initiated.
Symptoms of an allergic reaction to acamprosate include:
Sudden, raised red spots on your body.
Swelling of the throat, mouth, lips or tongue.
Feeling lightheaded, weak, confused and restless.1
You cannot take acamprosate if you have severe kidney problems,2 and it is not recommended for use during pregnancy.2
Research demonstrates that you should take acamprosate for 3 to 12 months to achieve the best results. 2 Although not required, most healthcare providers will encourage you to take each dose with a meal: one with breakfast, one with lunch and one with dinner. 2
If you miss a dose, wait until your next scheduled dose. You should never take extra doses to make up for a missed dose. 2
If you are taking naltrexone with acamprosate, your blood levels of acamprosate will increase. But this does not appear to have any clinical significance.2
Avoid alcohol when taking this medication. However, if you do relapse, continue taking acamprosate as prescribed and call your healthcare provider. 2
How Effective Is It?
Several studies have examined acamprosate's effectiveness.
A 2010 study demonstrated that acamprosate was beneficial in the management of alcohol use disorder by reducing cravings and helping to maintain abstinence.6 This study analyzed the results of 24 randomized controlled trials with a total of 6,894 alcohol-dependent patients. The review concluded that acamprosate reduces the risk of relapse after a person completes an alcohol detox program and that this medication works best for those who are already abstinent and who intend on remaining abstinent.
Another systemic review published in 2014 compared acamprosate to naltrexone (another medication used to treat alcoholism) and their effects on a person's likelihood of returning to drinking after undergoing an alcohol detoxification program.7 The review included 122 randomized-controlled trials and 22,803 participants. This study found that both medications equally reduced a person's risk of returning to drinking.
Additionally, a 2008 meta-analysis also compared acamprosate to naltrexone.8 This study concluded that acamprosate was more effective at helping people maintain abstinence, while naltrexone was more effective at preventing relapses for heavy, binge drinking.
Find an Alcohol Abuse Treatment Program
Alcohol abuse can have serious consequences to your health, your loved ones and your future. Fortunately, a variety of effective treatment options are available, including acamprosate therapy.
If you or someone you know is interested in a treatment program for alcoholism, please call our free, 24-hour helpline at 1-888-319-2606 . We can verify your insurance and determine treatment coverage. If you do not have insurance, please call the Substance Abuse and Mental Health Services Administration's (SAMHSA) national helpline at 1-888-319-2606 (HELP).
. Chisholm-Burns, S., Schwinghammer, T., Wells, B., Malone, P., & DiPiro, J. (2013). Pharmacotherapy principles and practice (3rd ed.). New York, NY: McGraw-Hill Medical.
. Stahl, S. M. (2014). Prescriber's guide: Stahl's essential psychopharmacology (5th ed.). New York: NY: Cambridge University Press.
. Sadock, B. J., Sadock, V. A., & Ruiz, P. (2015). Synopsis of psychiatry (11th ed.). Philadelphia, PA: Wolters Kluwer.
. Gabbard, G. O. (2014). Gabbard's treatments of psychiatric disorders (5th ed.). Washington, DC: American Psychiatric Association.
. Jhanjee, S. (2014). Evidence based psychosocial interventions in substance abuse . Indian Journal of Psychological Medicine. 36(2),112-118. doi: 10.4103/0253-7176.130960
. Rosner, S., Hackl-Herrwerth, A., Leucht, S., Lehert, P., Vecchi, S., & Soyka, M. (2010). Acamprosate for alcohol dependence . Cochrane Database of Systematic Reviews. 2010(9), CD004332. doi: 10.1002/14651858.CD004332.pub2
. Jonas, D. E., Amick, H. R., Feltner, C., Bobashev, G., Thomas, K., Wines, R., Garbutt, J.C. (2014). Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis . JAMA. 311(18), 1889-1900. doi: 10.1001/jama.2014.3628
. Rosner, S., Leucht, S., Lehert, P., & Soyka, M. (2008). Acamprosate supports abstinence, naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes . Journal of Psychopharmacology. 22(1), 11-23.
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